This study investigated the neurocognitive and electrophysiological effects of a citicoline-caffeine-based beverage in 60 healthy adult participants who were enrolled in a randomized, double-blind, placebo-controlled trial. Electrical brain activity was measured using electroencephalogram (EEG) and neuropsychological measures of attention, concentration, and reaction time were performed. Compared to placebo, participants receiving the citicoline-caffeine beverage demonstrated significantly faster maze learning times and reaction times on a continuous performance test, made fewer errors on a go/no-go task, and demonstrated greater accuracy on a measure of information processing speed. EEG results examining P450 event-related potentials showed that participants receiving the citicoline-caffeine beverage exhibited higher P450 amplitudes than controls, suggesting an increase in sustained attention. Overall, these results suggest that the beverage significantly improved sustained attention, cognitive effort, and reaction time in healthy adults. Evidence of improved P450 amplitude indicates a general improvement in the ability to hold new and relevant information within working memory and an overall increased activation of the brain.
Source: https://pubmed.ncbi.nlm.nih.gov/25046515/
