Several changes in magnesium (Mg) metabolism have been reported with aging, including reduced Mg intake, impaired intestinal Mg absorption, and renal Mg depletion. Mild Mg deficiency is usually asymptomatic, and clinical signs are usually nonspecific or absent. Elderly individuals with mild Mg deficiency often present with asthenia, sleep disturbances, hyperemotional and cognitive impairment, which are often confused with age-related symptoms. Chronic Mg deficiency increases the production of free radicals, which are implicated in the development of many chronic age-related disorders. Several human diseases have been associated with Mg deficiency, including cardiovascular disease, hypertension and stroke, cardiometabolic syndrome and type 2 diabetes mellitus, airway constriction syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer's disease (AD) and other dementia syndromes, muscle diseases (myalgia, chronic fatigue and fibromyalgia), bone fragility and cancer. Correction of Mg deficiency should consider Mg intake in drinking water and/or Mg (generally more biologically available than Mg in food) or in alternative Mg supplements. Maintaining optimal magnesium balance throughout life may help prevent oxidative stress and chronic diseases associated with aging. This needs to be proven in future studies.
Source: https://pubmed.ncbi.nlm.nih.gov/33573164/
