Magnesium deficiency and stress are both common conditions in the general population, which over time can increase the risk of health consequences. Several preclinical and clinical studies have investigated the interaction of magnesium with key mediators of the physiological stress response and have shown that magnesium plays a key inhibitory role in the regulation and neurotransmission of the normal stress response. In addition, low magnesium levels have been reported in several studies that assessed the nutritional aspects of subjects suffering from psychological stress or related symptoms. The overlapping findings suggest that stress may increase magnesium loss, leading to deficiency; and magnesium deficiency may increase the body's sensitivity to stress, resulting in a magnesium-stress vicious cycle. This review revisits the concept of the magnesium-stress vicious cycle, first introduced in the early 1990s, in light of the most recent available data.
Source: https://pubmed.ncbi.nlm.nih.gov/33260549/
